姓名：李静
性别：女
职称：副教授/副主任技师
学历：博士
学位：博士
最高学位的毕业院校：山东大学
工作单位：检验医学院实验室管理学教研室（第一附属医院，检验科）
学术领域：感染与炎症相关性疾病
研究方向：感染与免疫；炎症性肠病；病原菌耐药机制
一、科研和教研成果：
· 科研项目：
(1) 安徽高校自然科学研究项目，一般项目，YQYB2023019，优秀青年教师培育项目，2023-10-01至2026-09-30，5万元，在研，主持
(2) 安徽高校自然科学研究项目，优秀青年项目，2022AH030138，基于脂肪组织对间充质干细胞的趋化作用探讨克罗恩病肠系膜脂肪炎性增生的机制，2023-01-01至2025-12-31，50万元，在研，主持
(3) 安徽省卫生健康委科研项目，一般项目，AHWJ2022b088，基于宏蛋白质组建立细菌蛋白复合诊断模型用于结直肠肿瘤早期筛查，2022-12-31至2024-12-31，10万元，在研，主持
(4) 蚌埠医科大学自然科学基金项目，面上项目，2023byfy002，转录因子Ovol2 调控肠系膜脂肪细胞分化不良对克罗恩病的作用和机制，2024-01-01至2024-12-31，10万元，在研，主持
(5) 蚌埠医科大学第一附属医院基金项目，优秀青年项目，2019byyfyyq02，Pygopus 2 调控肠系膜脂肪组织在克罗恩病肠道炎症中的作用及机制，2019-11-01至2023-11-30，40万元，在研，主持
(6) 国家自然科学基金，青年项目，81902078，NK细胞外泌体IFNG-AS1促进M1型巨噬细胞极化抵御衣原体肺部感染的作用及机制，2020-01-01至2022-12-31，20万元，结题，主持
· 论文发表：
(1) Geng Zhijun*,Zuo Lugen*,Li Jing*,Yin Lixia,Yang Jingjing,Duan Ting,Wang Lian,Zhang Xiaofeng,Song Xue,Wang Yueyue,Hu Jianguo#. Ginkgetin improved experimental colitis by inhibiting intestinal epithelial cell apoptosis through EGFR/PI3K/AKT signaling. FASEB Journal. 2024;38(14):e23817. 中科院二区, IF=4.4.
(2) Li Qingqing*,Li Jing*,Yin Lixia,Huang Ju,Liu Xinyue,Shi Jinran,Geng Zhijun,Song Xue,Wang Lian,Wang Yueyue,Zhang Xiaofeng,Zuo Lugen,Hu Jianguo#. Sophoricoside improved Crohn’s disease-like colitis by inhibiting intestinal epithelial cell apoptosis through PI3K/AKT signaling. International Immunopharmacology. 2024.131:111886. 中科院二区, IF=5.6.
(3) Geng Zhijun*,Li Jing*,Zuo Lugen*,Zhang Xiaofeng*,Wang Lian,Xia Yongsheng,Yang Jingjing,Yin Lixia,Song Xue,Wang Yueyue,Chai Damin,Deng Min,Ge Yuanyuan,Wu Rong,Hu Jianguo#. Intestinal adipocytes transdifferentiate into myofibroblast-like cells and contribute to fibrosis in Crohn's disease. Journal of Crohns & Colitis. 2024.. 中科院二区, IF=8.0.
(4) Cheng Yang*,Li Jing*,Wang Lian,Wu Xiaopei,Li Yuetong,Xu Mengyu,Li Qingqing,Huang Ju,Zhao Tianhao,Yang Zi,Zhang Hao,Zuo Lugen,Zhang Xiaofeng,Geng Zhijun,Wang Yueyue,Song Xue#,Zhang Jun#. Eriocalyxin B ameliorated Crohn's disease-like colitis by restricting M1 macrophage polarization through JAK2/STAT1 signalling. European Journal of Pharmacology. 2023.954:175876. 中科院二区, IF=5.0.
(5) Zhang Hao*,Zuo Lugen*,Li Jing*,Geng Zhijun,Ge Sitang,Song Xue,Wang Yueyue,Zhang Xiaofeng,Wang Lian,Zhao Tianhao,Deng Min,Chai Damin,Wang Qiusheng,Yang Zi,Liu Quanli,Qiu Quanwei,He Xuxu,Yang Yiqun,Ge Yuanyuan,Wu Rong,Zheng Lin,Li Jianjun,Chen Runkai,Sun Jialiang,Hu Jianguo#. Construction of a fecal immune-related protein-based biomarker panel for colorectal cancer diagnosis: a multicenter study. Frontiers in Immunology. 2023.14:1126217. 中科院二区, IF=8.786.
(6) Zuo Lugen*,Li Jing*,Zhang Xiaofeng*,Geng Zhijun,Song Xue,Wang Yueyue,Ge Sitang,Shi Ruohan,Zhou Yueqing,Ge Yuanyuan,Wu Rong,Hu Jianguo#. Aberrant mesenteric adipose extracellular matrix remodelling is involved in adipocyte dysfunction in Crohn’s Disease: the role of TLR-4-mediated macrophages. Journal of Crohns & Colitis. 2022.16(11):1762-1776. 中科院二区, IF=10.02.
(7) Li Jing*,Zuo Lugen*,Geng Zhijun,Li Qingqing,Cheng Yang,Yang Zi,Shi Ruohan,Zhou Yueqing,Nie Wenhu,Wang Yueyue,Zhang Xiaofeng,Ge Sitang,Song Xue,Hu Jianguo#. Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Crohn's disease -like colitis via the Axin2/GSK3β pathway. Cell Proliferation. 2022.55(10):e13292. 中科院一区, IF=8.755.
(8) Geng Zhijun*,Li Jing*,Li Sandang,Wang Yueyue,Zhang Lele,Hu Qiuzi,Wang Xinru,Zuo Lugen,Song Xue,Zhang Xiaofeng,Ge Sitang,Hu Jianguo#. MAL protein suppresses the metastasis and invasion of GC cells by interfering with the phosphorylation of STAT3. Journal of Translational Medicine. 2022.20(1):50. 中科院二区, IF=7.4.
(9) Zhao Lei*,Li Jing*,Pan Qianqian,Zhao Weiming,Yang Xi,Wang Hong#. Natural Killer Cells Regulate Pulmonary Macrophages Polarization in Host Defense Against Chlamydial Respiratory Infection. Frontiers in Cellular and Infection Microbiology. 2021.11:775663. 中科院二区, IF=5.6998.
(10) Song Xue*,Li Jing*,Wang Yan,Zhou Changmin,Zhang Zhichao,Shen Mengdi,Xiang Ping,Zhang Xiaofeng,Zhao Hao,Yu Liang,Zuo Lugen,Hu Jianguo#. Clematichinenoside AR ameliorated spontaneous colitis in Il-10−/− mice associated with improving the intestinal barrier function and abnormal immune responses. Life Sciences. 2019.239:117021. 中科院二区, IF=3.448.
二、研究方向（需要有较具体的内容简介）与招生信息：（此段的介绍可有自己的特色）：
主要研究方向为炎症性肠病、病原菌耐药机制、感染与免疫等。
三、指导学生情况：
已指导培养硕士研究生2名，其中1名学生获得国家奖学金。
