
姓名:刘辉,性别:男,职称:教授;
学历:博士研究生,学位:博士;
最高学位的毕业院校:中国科学院大学;
工作单位:检验医学院生物化学与分子生物学教研室;
学术领域:基础医学、临床检验诊断学、医学检验技术;
研究方向:脂质代谢稳态调控机制;内分泌干扰物与脂质代谢;脂代谢相关疾病发病机制。
一、科研成果:
l 科研项目:
1. 主持国家自然科学基金青年项目,《PPARα/ACOT1信号通路在全氟辛酸暴露致大鼠脂肪酸代谢紊乱中的作用研究》(项目编号:21806002),起止时间:2019-01到2021-12,资助经费:24.5万元。
2. 主持安徽省教育厅重大项目,《PPARα调控脂质代谢稳态在PFNA诱导的早期动脉粥样硬化中的机制研究》(项目批准号:2022AH040221),起止时间:2023-01到2025-12,资助经费:20万元。
3. 主持蚌埠医科大学重点支持和培育学科领域专项,《基于CRISPR-Cas9技术构建gdf6a基因敲除斑马鱼探索视网膜视锥细胞发育异常的机制》(项目编号:2023bypy011),起止时间:2024-01到2025-12,资助经费:20万元。
4. 主持慢性疾病免疫学基础与临床安徽省重点实验室科研平台开放课题,《内分泌干扰物HPFO-TA致OX-LDLC蓄积引起心血管内皮细胞炎症反应的免疫机制研究》(项目批准号:KLICD-2023-Z1),起止时间:2024-01到2025-12,资助经费:6万元。
5. 主持安徽省高校优秀拔尖人才培育资助项目,《高校优秀青年人才支持计划重点项目》(项目编号:gxyqZD2020028),起止时间:2020-08到2023-08,资助经费:6万元。
6. 主持安徽省高校优秀拔尖人才培育资助项目,《高校优秀青年骨干人才国外访学项目》(项目编号:gxfx2017065),起止时间:2018-01到2020-03,资助经费:15万元。
l 学术论文发表
1. Bingya Zhang, Zhonghua Fan, Xuan Liu, Yuanyuan Wu, Lin Cheng, Li Wang*, Hui Liu*. Bisphenol AF induces lipid metabolism disorders, oxidative stress and upregulation of heat shock protein 70 in zebrafish. Comp Biochem Physiol C Toxicol Pharmacol, 10.1016/j.cbpc.2025.110164.
2. Xinxin Deng, Lin Cheng, Ying Qiao, Xuan Liu, Yongbing Zhou, Hui Liu*, Li Wang*. Rutin ameliorates HCD-induced cholesterol metabolism disorder in zebrafish larvae revealed by transcriptome and metabolome analysis. Phytomedicine,2024,16:135:156058. doi: 10.1016/j.phymed.2024.156058. 中科院1区TOP
3. Mingqing Qian, Weiqiang Sun, Lin Cheng, Yuanyuan Wu, Li Wang*, Hui Liu*. Transcriptome-based analysis reveals the toxic effects of perfluorononanoic acid by affecting the development of the cardiovascular system and lipid metabolism in zebrafish. Comp Biochem Physiol C Toxicol Pharmacol, 10.1016/j.cbpc.2024.110108.
4. Penghui Mao, Xuemin Zhang, Mingqing Qian, Qi Wang, Ying Yang, Yangli Gao, Hui Liu*, Li Wang* Transcriptomics-based analysis reveals hexafluoropropylene oxide trimer acid (HFPO-TA) induced kidney damage and lipid metabolism disorders in SD rats. Ecotoxicology and Environmental Safety, 2024, 29:283:116951, 中科院1区.
5. Mingqing Qian, Xijuan Ren, Penghui Mao, Zhi Li, Tingting Qian, Li Wang, Hui Liu*. 2024, Transcriptomics-based analysis reveals the nephrotoxic effects of triphenyltin (TPT) on SD rats by affecting RAS, AQPs and lipid metabolism, Pesticide Biochemistry and Physiology,199C: 105792,中科院1区TOP.
6. Xuemin Zhang, Zhi Li, Mingqing Qian, Bingya Zhang, Hongxia Zhang, Li Wang *, Hui Liu*. 2024, Transcriptome and Metabolome analysis reveal HFPO-TA induced disorders of hepatic glucose and lipid metabolism in rat by interfering with PPAR signaling pathway, Food and Chemical Toxicology,188: 114632.
7. Li Wang, Weiqiang Sun, Xinzhuang Ma, Nathan Griffin, Hui Liu*. 2024, Perfluorooctanoic acid (PFOA) exposure induces renal filtration and reabsorption disorders via downregulation of aquaporins, Toxicology Letters,392C: 22-35.
8. Xijuan Ren, Penghui Mao, Zhi Li, Mingqing Qian, Xinxin Deng, Hui Liu*, Li Wang*. 2024, TMT-based quantitative proteomics analysis of Sprague-Dawley rats liver reveals Triphenyltin induced liver damage and lipid metabolism disorders, Pesticide Biochemistry and Physiology,198C: 105739,中科院1区TOP.
9. Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu*, Li Wang*. 2024, Rutin ameliorate PFOA induced renal damage by reducing oxidative stress and improving lipid metabolism, The Journal of Nutritional Biochemistry,123C: 109501.
10. Ying Qiao, Yongbing Zhou, Xuemin Zhang, Sam Faulkner, Hui Liu*, Li Wang*. 2023, Toxic effects of triphenyltin on the development of zebrafish (Danio rerio) embryos,Science of the Total Environment,885C (5): 163783,中科院1区TOP.
二、研究方向与招生信息:
脂质代谢稳态调控机制;内分泌干扰物与脂质代谢;脂代谢相关疾病发病机制等领域的研究工作
三、指导学生情况:
已指导培养硕士研究生13名,4名已毕业,其中2人获国家奖学金荣