
姓名:唐王刚,男,职称:副教授,2016年6月取得安徽师范大学博士研究学历和博士学位,现为检验医学院生物化学与分子生物学教研室专任教师。
学术领域:蛋白质的表征、改造和生物信息学
研究方向:
(1)病原微生物关键酶的原核表达、表征和分子设计
(2)靶向疾病相关蛋白的计算机辅助的药物设计
(3)分子对接和分子动力学
一、科研成果:
· 科研项目:
1. 奈瑟菌hom6基因的进化机制探索,安徽省教育厅自然科学研究重点项目,研究期限:2023年8月至2025年7月,批准文号:2023AH051932,经费总额:10万元。
2. 淋球菌高丝氨酸脱氢酶的鉴定与虚拟筛选,安徽省教育厅自然科学研究重点项目,研究期限:2020年12月至2022年11月,批准文号:KJ2020A0551,经费总额:6万元。
· 发表论文:
1.Shuping Fei, Wenxiu Hu, Jingwen Shu, Ruirui Zhao, Jiatong Zhao, Mengwei Jiang, Wenwen Wu, Chaoqun Lian, Wanggang Tang(第一通讯作者). Expression and biochemical characterization of a novel NAD+-dependent xylitol dehydrogenase from the plant endophytic fungus Trichoderma gamsii. Protein Expr Purif, 2025, 229:106687.
2.Xue Dong, Tingting Zhang, Chuanyue Gui, Shuping Fei, Haonan Xu, Jianrong Chang, Chaoqun Lian, Wanggang Tang(第一通讯作者). The critical role of residues Phe120 and Val161 of (2 R,3 R)‑2,3‑butanediol dehydrogenase from Neisseria gonorrhoeae as probed by molecular docking and site‐directed mutagenesis. J Basic Microbiol, 2024, 64(6): e2300751.
3.Wanggang Tang, Chuanyue Gui, Tingting Zhang. Expression, Purification, and Bioinformatic Prediction of Mycobacterium tuberculosis Rv0439c as a Potential NADP(+)-Retinol Dehydrogenase. Mol Biotechnol, 2024, 66(12):3559-3572.
4.Rui Qiao, Wanggang Tang(共同第一作者), Jiayan Li, Chen Li, Chaoyue Zhao, Xun Wang, Minghui Li, Yuchen Cui, Yanjia Chen, Guonan Cai, Qingyu Wu, Xiaoyu Zhao, Pengfei Wang. Structure-based virtual screening of ROCK1 inhibitors for the discovery of Enterovirus-A71 antivirals. Virology, 2023, 585:205-214.
5.Wanggang Tang , Chaoqun Lian, Yu Si, Jianrong Chang. Purification and characterization of (2R,3R)-2,3-butanediol dehydrogenase of the human pathogen Neisseria gonorrhoeae FA1090 produced in Escherichia coli. Mol Biotechnol, 2021, 63(6):491-501.
6.Wanggang Tang, Mengqing Guo, Xu Jiang, Haonan Xu. Expression, purification, and biochemical characterization of an NAD+-dependent homoserine dehydrogenase from the symbiotic Polynucleobacter necessarius subsp. necessarius. Protein Expr Purif, 2021, 188:105977.
7.Wanggang Tang, Xue Dong, Jiang Meng, Yanan Feng, Manman Xie, Haonan Xu, Ping Song. Biochemical characterization and redesign of the coenzyme specificity of a novel monofunctional NAD+-dependent homoserine dehydrogenase from the human pathogen Neisseria gonorrhoeae. Protein Expr Purif, 2021, 186:105909.
8.Wanggang Tang, Minhao Wu, Na Qin, Li Liu, Rui Meng, Chengliang Wang, Peng Wang, Jianye Zang, Guoping Zhu. Crystal structures of NAD+-linked isocitrate dehydrogenase from the green alga Ostreococcus tauri and its evolutionary relationship with eukaryotic NADP+-linked homologs. Arch Biochem Biophys. 2021, 708:108898.
二、研究方向
病原微生物关键酶的原核表达、表征和分子设计以及靶向疾病相关蛋白的计算机辅助的药物设计等领域的研究工作
三、指导学生情况:
已指导培养硕士研究生3名。