姓 名：唐王刚
性 别：男
出生年月：1988年10月
专业技术职称：副教授
导师类别：硕导
电子邮箱：tangwanggang@bbmu.edu.cn
一、主要研究方向
1. 病原微生物基础代谢酶的表征和改造
2. 肿瘤分子生物学
3. 计算生物学
二、个人简历
2016年博士毕业于安徽师范大学生物化学与分子生物学专业，博士在读期间曾获博士研究生国家奖学金。同年入职蚌埠医科大学（原蚌埠医学院）。近三年指导硕士研究生3名，其中2人荣获研究生学业一等奖学金。工作经历如下：
(1) 2024-01 至 今, 蚌埠医科大学，检验医学院，副教授
(2) 2021-12 至 2023-12，蚌埠医学院，检验医学院, 副教授
(3) 2017-12 至 2021-11，蚌埠医学院，检验医学院，讲师
(4) 2016-07 至 2017-11，蚌埠医学院，检验医学院，无
三、主持科研/教学项目
1. 奈瑟菌hom6基因的进化机制探索，安徽省教育厅自然科学研究重点项目，研究期限：2023年8月至2025年7月，批准文号：2023AH051932，经费总额：10万元，主持。
2. 淋球菌高丝氨酸脱氢酶的鉴定与虚拟筛选，安徽省教育厅自然科学研究重点项目，研究期限：2020年12月至2022年11月，批准文号：KJ2020A0551，经费总额：6万元，主持。
四、代表性成果
1. Fei Shuping, Zhao Jiatong, Wu Wenwen, Lian Chaoqun, Tang Wanggang. Biochemical characterization of histidinol dehydrogenase from the human pathogen Neisseria gonorrhoeae. Protein Expression and Purification, 2026, 237:106824. （通讯作者）
2. Chang Jianrong, Zhao Jiatong, Mei Lanlan, Wu Wenwen, Zhang Yunhan, Tang Wanggang. Biophysical characterization of heterologously expressed GrpE and bioinformatic analysis of its native sequence from Neisseria gonorrhoeae. Protein Expression and Purification, 2026, 241:106919. （通讯作者）
3. Tang Wanggang, Fei Shuping, Zhao Jiatong, Zhao Ruirui, Shu Jingwen, Hu Wenxiu, Zhu Guoping. Characterization of five Neisseria homoserine dehydrogenases with diverse coenzyme specificities reveals adaptive evolution of the hom6 genes. International Journal of Biological Macromolecules, 2025, 308:142603.
4. Fei Shuping, Hu Wenxiu, Shu Jingwen, Zhao Ruirui, Zhao Jiaotong, Jiang Mengwei, Wu Wenwen, Lian Chaoqun, Tang Wanggang. Expression and biochemical characterization of a novel NAD+-dependent xylitol dehydrogenase from the plant endophytic fungus Trichoderma gamsii. Protein Expression and Purification, 2025, 229:106687. （通讯作者）
5. Tang Wanggang, Gui Chuanyue, Zhang Tingting. Expression, Purification, and Bioinformatic Prediction of Mycobacterium tuberculosis Rv0439c as a Potential NADP(+)-Retinol Dehydrogenase. Molecular Biotechnology, 2024, 66(12):3559-3572.
6. Dong Xue, Zhang Tingting, Gui Chuanyue, Fei Shuping, Xu Haonan, Chang Jianrong, Lian Chaoqun, Tang Wanggang. The critical role of residues Phe120 and Val161 of (2 R,3 R)‑2,3‑butanediol dehydrogenase from Neisseria gonorrhoeae as probed by molecular docking and site-directed mutagenesis. Journal of Basic Microbiology, 2024:e202300751. （通讯作者）
7. Qiao Rui, Tang Wanggang, Li Jiayan, Li Chen, Zhao Chaoyue, Wang Xun, Li Minghui, Cui Yuchen, Chen Yanjia, Cai Guonan, Wu Qingyu, Zhao Xiaoyu, Wang Pengfei. Structure-based virtual screening of ROCK1 inhibitors for the discovery of Enterovirus-A71 antivirals. Virology, 2023, 585:205-214. （共同第一作者）
8. Tang Wanggang, Wu Minhao, Qin Na, Liu Li, Meng Rui, Wang Chengliang, Wang Peng, Zang Jianye, Zhu Guoping. Crystal structures of NAD+-linked isocitrate dehydrogenase from the green alga Ostreococcus tauri and its evolutionary relationship with eukaryotic NADP(+)-linked homologs. Archives of Biochemistry and Biophysics, 2021, 708:108898.
9. Tang Wanggang, Lian Chaoqun, Si Yu, Chang Jianrong. Purification and Characterization of (2R,3R)-2,3-Butanediol Dehydrogenase of the Human Pathogen Neisseria gonorrhoeae FA1090 Produced in Escherichia coli. Molecular Biotechnology, 2021, 63(6):491-501.
10. Tang Wanggang, Guo Mengqing, Jiang Xu, Xu Haonan. Expression, purification, and biochemical characterization of an NAD+-dependent homoserine dehydrogenase from the symbiotic Polynucleobacter necessarius subsp. necessarius. Protein Expression and Purification, 2021, 188:105977.
11. Tang Wanggang, Dong Xue, Meng Jiang, Feng Yanan, Xie Manman, Xu Haonan, Song Ping. Biochemical characterization and redesign of the coenzyme specificity of a novel monofunctional NAD+-dependent homoserine dehydrogenase from the human pathogen Neisseria gonorrhoeae. Protein Expression and Purification, 2021, 186:105909.
