姓 名：许 涛
性 别：男
出生年月：1985年9月
专业技术职称：副教授
导师类别：硕导
电子邮箱：taoxu@bbmu.edu.cn
一、主要研究方向
1. 病原微生物致病机制研究
2. 纳米颗粒疫苗设计与免疫机制研究
二、个人简历
许涛，医学博士，博士后，副教授，硕士研究生导师，蚌埠医科大学512人才培育计划获得者、获安徽省科技进步二等奖等。致力于病原微生物生物学特性、宿主免疫互作机制及新型疫苗研发等研究。主持和参加多项国家、省部级科研项目等多项，相关成果在《Cell Mol Biol Lett》、《Virulence》、《Int J Biol Macromol》等期刊发表，申请获批国家发明专利多项。
三、主持科研/教学项目
1. 安徽省教育厅重点项目，2024AH051295，2024/09-2026/09，10万元，主持。
2. 蚌埠医科大学自然科学基金重点项目，2023byzd020，2024/01-2025/12，5万元，主持。
3. 慢性疾病免疫学基础与临床安徽省重点实验室开放研究基金，KLICD-2022-Z3，2022/01-2023/12，6万元，主持。
4. 安徽省自然科学基金项目，2008085QH405，2020/07-2022/06，10万元，主持。
5. 蚌埠医科大学512人才培育计划，by51201309，2020/05-2023/05，30万元，主持。
四、代表性成果（论文/专利/专著等）
代表性论文：
1. Sihang Dong, Shuang Wu, Ke Liang, Hui Zhang, Fangzheng Guo, Yamin Song, Yanmei Hao, Zhongqing Qian, Xiaojing Wang, Tao Xu*, Hongtao Wang*. Immunogenicity Enhancement via Self-Assembled mi3 Nanoparticles Displaying ESAT-6 Antigen. International journal of nanomedicine (IF: 6.5). 2026, 21:558312.
2. Yamin Song, Fangzheng Guo, Huiting Dai, Xiaoyu Zhou, Sihang Dong, Hui Zhang, Zhongqing Qian, Baiqing Li, Xiaojing Wang, Tao Xu*, Hongtao Wang*. The mechanism regulating the cytotoxicity of γδ T cells activated by mycobacterium tuberculosis heat-resistant antigen based on RNA-seq analysis, Frontiers in immunology (IF: 5.9), 2026, 17:1707304.
3. Fangzheng Guo, Sihang Dong, Yamin Song, Yuanyuan Qian, Hairui Jiang, Wutong Zhang, Baiqing Li, Zhongqing Qian, Xiaojing Wang, Guangxian Xu*, Hongtao Wang*, Tao Xu*. Self-assembled ferritin tuberculosis nanovaccines targeting ESAT-6 and CFP-10 elicit potent immunogenicity in mice., international journal of biological macromolecules (IF: 8.5), 2025, 320(Pt 4):146101.
4. Fangzheng Guo, Sihang Dong, Yamin Song, Ge Xiesihan, Hairui Jiang, Zhongqing Qian, Xiaojing Wang, Hongtao Wang*, Tao Xu*. Self-assembled ferritin nanoparticles using SpyCatcher/SpyTag multimerization of Mycobacterium tuberculosis TB10.4 protein induce potent immunogenic, International immunopharmacology (IF: 4.7). 2025, 161:115019.
5. Fangzheng Guo, Yamin Song, Sihang Dong, Jing Wei, Baiqing Li, Tao Xu*, Hongtao Wang*, Characterization and anti-tuberculosis effects of γδ T cells expanded and activated by Mycobacterium tuberculosis heat-resistant antigen, Virulence (IF: 5.4). 2025, 16(1):2462092.
6. Jing Wei, Fangzheng Guo, Yamin Song, Tong Feng, Ying Wang, Kun Xu, Jianhan Song, Eldana Kaysar, Reyima Abdukayyum, Feiyang Lin, Kangsheng Li, Baiqing Li, Zhongqing Qian, Xiaojing Wang, Hongtao Wang*, Tao Xu*. Analysis of the components of Mycobacterium tuberculosis heat-resistant antigen (Mtb-HAg) and its regulation of γδ T-cell function. Cellular & molecular biology letters (IF: 10.2). 2024, 29(1):70.
7. Fangzheng Guo, Jing Wei, Ya-Min Song, Jianhan Song, Ying Wang, Kangsheng Li, Baiqing Li, Zhongqing Qian, Xiaojing Wang, Hongtao Wang, Tao Xu*. Immune responses induced by Mycobacterium tuberculosis heat-resistant antigen (Mtb-HAg) upon co-administration with Bacillus Calmette-Guérin in mice. Cytokine (IF: 3.7). 2024, 179: 156610.
8. Tao Xu, Chutong Wang, Minying Li, Jing Wei, Zixuan He, Zhongqing Qian, Xiaojing Wang, Hongtao Wang*. 2024, Mycobacterium tuberculosis PE_PGRS45 (Rv2615c) Promotes Recombinant Mycobacteria Intracellular Survival via Regulation of Innate Immunity, and Inhibition of Cell Apoptosis. Journal of microbiology (IF: 2.6). 62(1):49-62.
9. Fangzheng Guo, Jing Wei, Yamin Song, Baiqing Li, Zhongqing Qian, Xiaojing Wang, Hongtao Wang,* Tao Xu*. Immunological effects of the PE/PPE family proteins of Mycobacterium tuberculosis and related vaccines. Frontiers in Immunology (IF: 5.9), 2023, 14:1255920.
10. Jing Wei, Fangzheng Guo, Yamin Song, Kun Xu, Feiyang Lin, Kangsheng Li, Baiqing Li, Zhongqing Qian, Xiaojing Wang, Hongtao Wang*, Tao Xu*. Transcriptional analysis of human peripheral blood mononuclear cells stimulated by Mycobacterium tuberculosis antigen. Frontiers in Cellular and Infection Microbiology (IF: 4.8), 2023, 13:1255905.
11. Tao Xu, Chutong Wang, Minying Li, Meili Yuan, Jing Wei, Baiqing Li, Zhongqing Qian, Ting Wang, Xiaojing Wang, Hongtao Wang*. Mycobacterium tuberculosis PE8 (Rv1040c) Promotes the Intracellular Survival of Recombinant Mycobacterium by Regulating Host Inflammatory Cytokines and Inhibiting Cell Late Apoptosis. 2023, DNA and Cell Biology (IF: 2.6), 42(5): 254-264.
专利：
1.许涛，郭方正，汪洪涛，董思航，宋亚敏，钱袁媛，姜海瑞，张吴彤，李柏青，钱中清，王效静。一种靶向结核病亚基抗原的自组装铁蛋白纳米疫苗及制备方法和应用，2025年，中国，ZL202510138770.0
2. 许涛，郭方正，汪洪涛，董思航，宋亚敏，吴双，梁珂，姜海瑞，钱中清，王效静。一种自组装铁蛋白纳米颗粒重组蛋白SFT及其制备方法和应用，2025年，中国，ZL202510275824.8
3. 许涛，魏婧，汪洪涛，宋亚敏，郭方正，王楚彤，袁美丽，钱中清，王效静。结核分枝杆菌GroES重组蛋白的制备方法及其应用，2023年，中国，CN202310589733.2
4. 许涛，魏婧，汪洪涛，宋亚敏，郭方正，王楚彤，袁美丽，钱中清，王效静。结核分枝杆菌GroEL1重组蛋白的制备方法及其应用，2023年，中国，CN202310589726.2
5. .汪洪涛，郭方正，许涛，魏婧，宋亚敏，董思航，钱中清，王效静，宋健涵，王颖，李康生。一种结核分枝杆菌耐热抗原的应用，2025年，中国，ZL 2024 1 0200775.7
