姓 名：刘辉
性 别：男
出生年月：1983年12月
专业技术职称：教授
导师类别：硕导/博导
工作单位：蚌埠医科大学
电子邮箱：liuhui@bbmu.edu.cn
一、主要研究方向
1. 环境化学与人类健康
2. 脂质代谢稳态调控机制；脂代谢相关疾病发病机制。
二、个人简历
包括学习工作经历，人才称号，学术兼职，获奖及个人荣誉等。
刘辉，蚌埠医科大学生化与分子生物学教研室副主任，博士，教授，博士研究生导师，博士后合作导师。中国科学院大学生物化学与分子生物学专业博士，澳大利亚纽卡斯尔大学生物医学科学与药学院医学生物化学专业博士后。中国环境科学学会持久性有机污染物专业委员会委员、安徽省生物化学与分子生物学会理事、安徽省优秀青年研究生导师。主持国家自然科学基金、安徽省自然科学基金、安徽省高校拔尖人才培育项目等。主要从事内分泌干扰物与人类健康及脂质代谢紊乱相关疾病的研究工作，近5年来以第一作者或通讯作者在Phytomedicine，Chemico-Biological Interactions，Toxicology，The Journal of Nutritional Biochemistry，Proteomics等杂志发表SCI科研论文三十余篇。主要承担临床医学、麻醉学、预防医学、药理学等专业的《生物化学》《生物化学与分子生物学》等课程的教学。
三、主持科研/教学项目
科研项目：
1. 国家自然科学基金青年项目，21806002，PPARα/ACOT1信号通路在全氟辛酸暴露致大鼠脂肪酸代谢紊乱中的作用研究，2019/01-2021/12，24.50万元，主持。
2. 安徽省自然科学基金青年项目，1608085QH192，全氟烷酸致肝脏脂代谢紊乱的机制研究及敏感标志物的遴选，2016/07-2018/06，8万元，主持。
3. 安徽省高校自然科学研究重大项目，2022AH040221，PPARα调控脂质代谢稳态在PFNA诱导的早期动脉粥样硬化中的机制研究，2023/01-2025/12，20万元，主持。
4. 横向课题，BYDH2025015，自动化检验分析仪清洗液的研发，2025/09-2030/09，50万元，主持。
5. 蚌埠医科大学重点支持和培育学科领域专项，2023bypy011，基于CRISPR-Cas9技术构建gdf6a基因敲除斑马鱼探索视网膜视锥细胞发育异常的机制，2024/01-2025/12，20万元，主持。
6. 慢性疾病免疫学基础与临床安徽省重点实验室科研平台开放课题，KLICD-2023-Z1，内分泌干扰物HPFO-TA致OX-LDLC蓄积引起心血管内皮细胞炎症反应的免疫机制研究，2024/01-2025/12，6万元，主持。
7. 安徽省教育厅，gxfx2017065，高校优秀青年骨干人才国外访学研修项目，2017/03-2020/03，15.0万元，主持。
8. 安徽省教育厅，gxyqZD2020028，高校优秀青年人才支持计划重点项目，2020/08-2023/08，6.0万元，主持。
教学项目：
1. 新时代育人省级质量工程项目，2024qyw/sysfkc038，（研究生教育）《高级生物化学（全英文/双语）》，2025/05-2027/05，4.0万元，主持。
2. 省级重点教学研究项目，2022jyxm994，立德树人引领下基于成果导向的《生物化学》混合式教学体系构建与实践，2023/01-2024/12，2.0万元，主持。
3. 省级重点教学研究项目，2019jyxm0247，国际化背景下基于多元化信息共享的生物化学双语课程探索与实践，2019/12-2021/12，2.0万元，主持。
4. 大规模在线开放课程（MOOC）示范项目，2019mooc189，生物化学（双语课程），2019/12-2021/12，6.0万元，主持。
四、代表性成果（论文/专利/专著等）
代表性论文：
1. Xuan Liu, Xijuan Ren, Zhonghua Fan, Penghui Mao, Mingqing Qian, Tingting Qian, Ying Yang, Hui Liu, Li Wang. Metabolomics analysis reveals lipid metabolism disorders caused by triphenyltin via upregulation of PPARγ pathway. Ecotoxicology and Environmental Safety, 2025, 1:306:119359.
2. Tingting Qian, Zhonghua Fan, Xiyue Liu, Ying Yang, Lin Cheng, Zhou Zhou, Ziheng Xiao, Lijuan Yuan, Li Wang, Hui Liu. Transcriptomic analysis reveals the toxic effects of Clothianidin on the embryonic development of zebrafish. Toxicology and Applied Pharmacology, 2025, 505: 117597.
3. Zhonghua Fan, Xu Fang, Lin Cheng, Xuan Liu, Yuanyuan Wu, Tingting Qian, Mengjiao Li, Wenyi Li, Li Wang, Hui Liu. Metabolomic insights into clothianidin induced disorders of hepatic lipid metabolism in mice via AMPK signaling pathway. Ecotoxicology and Environmental Safety, 2025, 305: 119217.
4. Xu Fang, Zhonghua Fan, Mengjiao Li, Zhi Li, Lin Cheng, Yuanyuan Wu, Li Wang, Hui Liu. HFPO-TA exposure triggers hepatomegaly and lipid peroxidation via Nrf2/keap1 antioxidant dysregulation and ferroptosis activation in the liver. Chemico-Biological Interactions, 2025, 421: 111765.
5. Yuanyuan Wu, Yuhong Jiang, Zhonghua Fan, Xuan Liu, Weiqiang Sun, Li Wang, Hui Liu. PFOA exposure causes kidney injury via disruption of lipid metabolism mediated by PPARα signaling pathway: An integrated analysis. Toxicology Letters, 2025, 413: 111736.
6. Lin Cheng, Zhonghua Fan, Yu Zhang, Xu Fang, Yuanyuan Wu, Hongru Liu, Lanxi Ye, Li Wang, Hui Liu. HFPO-TA induces liver damage and ferroptosis in zebrafish by disrupting iron metabolism homeostasis. Comp Biochem Physiol C Toxicol Pharmacol, 2025, 298C: 110318.
7. Yuanyuan Wu, Weiqiang Sun, Xiyue Liu, Zhonghua Fan, Lin Cheng, Ying Yang, Li Wang, Hui Liu. PFOA and its substitutes disrupt fatty acid metabolism and impair erythrocyte homeostasis in zebrafish. Ecotoxicol Environ Saf, 2025, 302C: 118546.
8. Zhi Li, Yuanyuan Wu, Mingqing Qian, Bingya Zhang, Xinxin Deng, Penghui Mao, Zhonghua Fan, Xu Fang, Lin Cheng, Xuan Liu, Li Wang, Hui Liu. Multi-Omics Analysis Reveals BPF Exposure Causes Hepatic Glucose and Lipid Metabolism Disorder in Rats by Disrupting Energy Homeostasis. Toxicology, 2025, 515C: 154130.
9. Bingya Zhang, Zhonghua Fan, Xuan Liu, Yuanyuan Wu, Lin Cheng, Li Wang, Hui Liu. Bisphenol AF induces lipid metabolism disorders, oxidative stress and upregulation of heat shock protein 70 in zebrafish. Comp Biochem Physiol C Toxicol Pharmacol, 2025, 293C: 110164.
10. Penghui Mao, Xuemin Zhang, Mingqing Qian, Qi Wang, Ying Yang, Yangli Gao, Hui Liu, Li Wang Transcriptomics-based analysis reveals hexafluoropropylene oxide trimer acid (HFPO-TA) induced kidney damage and lipid metabolism disorders in SD rats. Ecotoxicol Environ Saf, 2024, 283C:116951.
11. Mingqing Qian, Weiqiang Sun, Lin Cheng, Yuanyuan Wu, Li Wang, Hui Liu. Transcriptome-based analysis reveals the toxic effects of perfluorononanoic acid by affecting the development of the cardiovascular system and lipid metabolism in zebrafish. Comp Biochem Physiol C Toxicol Pharmacol, 2025, 289C :110108.
12. Xinxin Deng, Lin Cheng, Ying Qiao, Xuan Liu, Yongbing Zhou, Hui Liu, Li Wang. Rutin ameliorates HCD-induced cholesterol metabolism disorder in zebrafish larvae revealed by transcriptome and metabolome analysis. Phytomedicine, 2024, 135C:156058.
13. Mingqing Qian, Xijuan Ren, Penghui Mao, Zhi Li, Tingting Qian, Li Wang, Hui Liu. Transcriptomics-based analysis reveals the nephrotoxic effects of triphenyltin (TPT) on SD rats by affecting RAS, AQPs and lipid metabolism, Pesticide Biochemistry and Physiology，2024, 199C: 105792.
14. Xuemin Zhang, Zhi Li, Mingqing Qian, Bingya Zhang, Hongxia Zhang, Li Wang, Hui Liu. Transcriptome and Metabolome analysis reveal HFPO-TA induced disorders of hepatic glucose and lipid metabolism in rat by interfering with PPAR signaling pathway, Food and Chemical Toxicology，2024, 188: 114632.
15. Li Wang, Weiqiang Sun, Xinzhuang Ma, Nathan Griffin, Hui Liu. Perfluorooctanoic acid (PFOA) exposure induces renal filtration and reabsorption disorders via downregulation of aquaporins, Toxicology Letters，2024, 392C: 22-35.
16. Xijuan Ren, Penghui Mao, Zhi Li, Mingqing Qian, Xinxin Deng, Hui Liu, Li Wang. TMT-based quantitative proteomics analysis of Sprague-Dawley rats liver reveals Triphenyltin induced liver damage and lipid metabolism disorders, Pesticide Biochemistry and Physiology，2024, 198C: 105739.
17. Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang. Rutin ameliorate PFOA induced renal damage by reducing oxidative stress and improving lipid metabolism, The Journal of Nutritional Biochemistry，2024, 123C: 109501.
18. Ying Qiao, Yongbing Zhou, Xuemin Zhang, Sam Faulkner, Hui Liu, Li Wang. Toxic effects of triphenyltin on the development of zebrafish (Danio rerio) embryos，Science of the Total Environment，2023, 885C (5): 163783.
19. Weiqiang Sun, Xuemin Zhang, Ying Qiao, Nathan Griffin, Hongxia Zhang, Li Wang, Hui Liu. Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish. Ecotoxicology and Environmental Safety，2023, 259: 115020.
20. XijuanRen，XueminZhang，Xinzhuang Ma，Hui Liu，Li Wang. Triphenyltin (TPT) exposure causes SD rat liver injury via lipid metabolism disorder and ER stress revealed by transcriptome analysis，Toxicology Letters，2023, 381 (5): 60-71.
21. Xuemin Zhang, Xijuan Ren, Weiqiang Sun, Nathan Griffin, Li Wang, Hui Liu. PFOA exposure induces aberrant glucose and lipid metabolism in the rat liver through the AMPK/mTOR pathway. Toxicology，2023, 5 (24): 153551.
22. Hui Liu, Weiqiang Sun, Yongbing Zhou, Nathan Griffin, Sam Faulkner, Li Wang. iTRAQ-Based Quantitative Proteomics Analysis of Sprague-Dawley Rats Liver Reveals Perfluorooctanoic acid-induced Lipid Metabolism and Urea Cycle Dysfunction, Toxicology Letters，2022, 357 (3): 20-32.
23. Xiang Li, Hui Liu (co-first author), Matthew D Dun, Sam Faulkner, Xiaoming Liu, Chen Chen Jiang, Hubert Hondermarck. Proteome and secretome analysis of pancreatic cancer cells. Proteomics，2022, 7: e2100320.
24. Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Nathan Griffin, Hui Liu, Li Wang. Rutin ameliorates perfluorooctanoic acid-induced testicular injury in mice by reducing oxidative stress and improving lipid metabolism，Drug and Chemical Toxicology，2022, 11 (3): 1-12.
25. Yongbing Zhou, Ying Qiao, Xuemin Zhang, Xingzhuang Ma, Hui Liu, Li Wang. PFOA exposure causes variations of Acot1 among tissues in rats, and Acot1 in serum can be potentially used as a sensitive marker for health monitoring，Toxicology Research，2022, 11 (5): 872-880.
26. Hui Liu, Jingjing Cheng, Yongbing Zhou, Fangfang Liu, Nathan Griffin, Sam Faulkner, Li Wang. Interactions of perfluorooctanoic acid with acyl-CoA thioesterase 1 (Acot1). Comparative Biochemistry and Physiology, Part C，2021, 250 (12): 109159.
