姓 名：杨清玲
性 别：女
出生年月：1974年03月
专业技术职称：教授
导师类别：硕导/博导
电子邮箱：0600132@bbmu.edu.cn
一、主要研究方向
1. 肿瘤分子生物学、分子诊断
2. 生物化学与分子生物学
二、个人简历
博士，教授，省重点实验室主任，博士生导师；安徽省学术和技术带头人后备人选、省教育厅优秀创新团队负责人；安徽省级教学名师、省级高水平导师、省级名师工作室负责人、省级教学团队带头人；先后主持国家自然科学基金面上项目、安徽省高校协同创新项目、安徽省自然科学基金、安徽省教育厅自然科学研究重大和重点项目等10余项；获批安徽省II类引才奖补平台；研究成果获得国家发明专利一项；以第一作者和通讯作者发表SCI论文30余篇；主持中国医药学研究生在线课程群建设重点项目、安徽省教学研究重大和重点项目等质量工程10余项，获得安徽省教学成果二等奖3项（第一）；主参编教材10余部。
三、主持科研/教学项目
1. 国家自然科学基金面上项目（81071848)：病毒趋化因子vMIP-Ⅱ N端重组肽抗乳腺癌及在前哨淋巴结诊断中的作用和机制研究，2012/01-2013/12，29万元，主持。
2. 蚌埠医科大学“揭榜挂帅”科研攻关项目（2025byjbgs003）：基于“泛拉曼组-多组学”技术乳癌 / 肠癌标志物筛选的技术攻关及临床应用，2025/07-2028/26，20万元，主持。
3. 安徽省高校优秀科研创新团队（2024AH010021）：肿瘤恶性演变机制和诊疗新技术研发创新团队，2024/07-2027/26，200万元，主持。
4. 安徽高校协同创新项目（GXXT-2022-064）：外泌体ncRNA双靶向调控CXCL12和PD-L1对免疫抑制微环境和乳腺癌细胞耐药的机制研究，2023/01-2025/12，120万元，主持。
四、代表性成果（论文/专利/专著等）
代表性论文：
1. Guohui T#, Bo P#, Liu Y#, Xu S, Ruonan L, Chengle Z, Qiong W, Ruorong R, Cai H, Wenrui W*, Changjie C*, Qingling Y*. Exosome RAB10 inhibits JAK1/STAT1 to hinder macrophage M1 polarization and promote tumor immune escape. Cell Commun Signal. 2026 Jan 26.
2. Ruonan Li#, Yuting Liu#, Bo Pang, Xingyu Liu, Chengle Zhu, Guohui Tang, Ruorong Ran, Wenrui Wang*, Changjie Chen*, Qingling Yang*. RAB10 mediates metabolic regulation of ferroptosis in breast cancer and synergistically remodels the tumour immune microenvironment via macrophage M2 polarization. International Immunopharmacology, 2026, 172:116201-116218.
3. Shi J#, Zhu C#, Xu S#, Ran R, Ye R, Xiao Y, Ji Y, Geng C, Tang G, Li R, Ding Y, Wang W, Yang Q*, Chen C*. Laminar double hydroxide-loaded miR-654-3p targets POU2F1-mediated metabolic reprogramming against colorectal cancer. Bioorg Chem. 2025, 167:109234-109250.
4. Guohui Tang#, Zheng Zhang#, Bo Pang, Ruonan Li, Yuting Liu, Haotian Cai, Wenrui Wang*, Changjie Chen *, Yurong Ou*, Qingling Yang*. Integrated multi-omics analysis identifies SELENOP and PKMYT1 as immune-metabolic hub genes in breast cancer. Biochemistry and Biophysics Reports, 2025, 43:102198.
5. Yuhan Xiao#, Ruorong Ran#, Chengle Zhu#, Yuxin Ji, Jiwen Shi, Ruyin Ye, Chenchen Geng, Ruonan Li, Guohui Tang, Wenrui Wang*, Qingling Yang*, Changjie Chen*. Layered double hydroxide-delivered si-NEAT1 inhibits breast cancer immune evasion and malignant progression by modulating the miR-141–3p/PD-L1 axis. Bioorganic Chemistry, 2025, (163):108742.
6. Yuxin Ji#,· Ruonan Li#,· Guohui Tang#,· Yuhan Xiao,· Ruyin Ye, Jiwen Shi, Chenchen Geng, Ruorong Ran, Chengle Zhu, Wenrui Wang*, Changjie Chen*, Qingling Yang*. Integrative proteomics and metabolomics analyses reveals the regulation of autophagy and ferroptosis by RAB10 through Slc37a2/mTOR pathway in breast cancer. Cellular and Molecular Life Sciences. 2025, 82:275.
7. Tao S#, Ji Y#, Li R, Xiao Y, Wu H, Ye R, Shi J, Geng C, Tang G, Ran R, Zhu C, Wang W, Chen C*, Yang Q*. Layered Double Hydroxide LDH-Loaded miR-141-3p Targets RAB10 Suppressing Cellular Autophagy to Reverse Paclitaxel Resistance in Breast Cancer. ACS Omega. 2025 Feb 10;10(6):5886-5899.
8. Wu Y#, Xiao Y#, Ding Y#, Ran R, Wei K, Tao S, Mao H, Wang J, Pang S, Shi J, Zhu C, Wan W, Yang Q*, Chen C*. Colorectal cancer cell-derived exosomal miRNA-372-5p induces immune escape from colorectal cancer via PTEN/AKT/NF-κB/PD-L1 pathway. Int Immunopharmacol. 2024 Sep 30;143(Pt 1):113261.
9. Huilan Mao#, Ruyin Ye#, Guohui Tang, Shuang Tao, Ke Wei, Yulun Wu,Siyan Pang, Jing Wang, Jiwen Shi, Yuxin Ji, Yuhan Xiao, Chenchen Geng,Wenrui Wang*, Changjie Chen*, Qingling Yang*. Drug-resistant exosome miR-99b-3p induces macrophage polarization and confers chemoresistance on sensitive cells by targeting PPP2CA. International Immunopharmacology, 2024, 142:113168.
10. Xinyu Wei#,, Shuang Tao#, Huilan Mao, Haitao Zhu, Lingyu Mao, Wenhao Pei, Xiuru Shi, Yingxiang Shi, Shiwen Zhang, Yulun Wu, Ke Wei, Jing Wang, Siyan Pang, Wenrui Wang, Changjie Chen*, Qingling Yang*. Exosomal lncRNA NEAT1 induces paclitaxel resistance in breast cancer cells and promotes cell migration by targeting miR-133b. Gene, 2023, 860:147230.
11. Yingxiang# Shi, Jing# Wang, Shuang Tao, Shiwen Zhang, Lingyu Mao, Xiuru Shi, Wenrui Wang, Changjie Cheng, Yurong Shi*, Qingling Yang*. miR-142-3p improves paclitaxel sensitivity in resistant breast cancer by inhibiting autophagy through the GNB2-AKT-mTOR Pathway. Cell Signal, 2023 Mar;103:110566.
