姓名：吕合作，性别：男，职称：教授，学历：研究生，学位：博士，最高学位的毕业院校：上海交通大学，工作单位：蚌埠医科大学第一附属医院检验科，学术领域：神经免疫学，研究方向：神经损伤与免疫
一、科研成果：
l 科研项目：
（1）《vMIP-II-Lamp2b基因修饰的M2型巨噬细胞来源的外泌体靶向治疗脊髓损伤的实验研究》、项目来源: 国家自然科学基金面上项目、下达时间:2021、批准文号: 82072416、经费总额:55万元（在研）
（2）《炎症小体活化对损伤脊髓局部免疫微环境的影响》、项目来源: 国家自然科学基金面上项目、下达时间:2018、批准文号: 81772321、经费总额:58万元（2021年结项）
（3）《第八批省“特支计划”卫生创新领军人才》、项目来源: 中共安徽省组织部、下达时间:2022、批准文号: 皖组办字[2022]21号、经费总额:50万元（在研）
l 论文发表：
1.Bian MM, Xu YM, Zhang L, Yan HZ, Gao JX, Fu GQ, Wang YY, Lü HZ. The beneficial effect of α-lipoic acid on spinal cord injury repair in rats is mediated through inhibition of oxidative stress: A transcriptomic analysis. J Spinal Cord Med. 2024 Apr 22:1-14. doi: 10.1080/10790268.2024.2342058. Epub ahead of print. PMID: 38647358.
2.Fu GQ, Wang YY, Xu YM, Bian MM, Zhang L, Yan HZ, Gao JX, Li JL, Chen YQ, Zhang N, Ding SQ, Wang R, Li JY, Hu JG, Lü HZ. Exosomes derived from vMIP-II-Lamp2b gene-modified M2 cells provide neuroprotection by targeting the injured spinal cord, inhibiting chemokine signals and modulating microglia/macrophage polarization in mice. Exp Neurol. 2024 Jul;377:114784.
3.Li J, Li M, Wang R, Lan J, Yu L, Gao J, Lü H, Fang Q, Wang F. Mitophagy protects against silver nanoparticle-induced hepatotoxicity by inhibiting mitochondrial ROS and the NLRP3 inflammasome. Ecotoxicol Environ Saf. 2024 Mar 15;273:116137. doi: 10.1016/j.ecoenv.2024.116137.
4.Pei W, Zhang Y, Zhu X, Zhao C, Li X, Lü H, Lv K. Multitargeted Immunomodulatory Therapy for Viral Myocarditis by Engineered Extracellular Vesicles. ACS Nano. 2024 Jan 30;18(4):2782-2799.
5.Sun Y, Song X, Geng Z, Xu Y, Xiao L, Chen Y, Li B, Shi J, Wang L, Wang Y, Zhang X, Zuo L, Li J, Lü H, Hu J. IL-11 ameliorates oxidative stress damage in neurons after spinal cord injury by activating the JAK/STAT signaling pathway. Int Immunopharmacol. 2024 Jan 25;127:111367.
6.Li JL, Fu GQ, Wang YY, Bian MM, Xu YM, Zhang L, Chen YQ, Zhang N, Ding SQ, Wang R, Fang R, Tang J, Hu JG, Lü HZ. The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis. PeerJ. 2023 Feb 21;11:e14929.
7.Qi Q, Wang XX, Li JL, Chen YQ, Chang JR, Xi J, Lü HZ, Zhang YX. Neuroprotective Effects of the Pannexin-1 Channel Inhibitor: Probenecid on Spinal Cord Injury in Rats. Front Mol Neurosci. 2022 May 19;15:848185.
8.Xue MT, Sheng WJ, Song X, Shi YJ, Geng ZJ, Shen L, Wang R, Lü HZ, Hu JG. Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization. CNS Neurosci Ther. 2022 Jul;28(7):1059-1071.
9.Shi YJ, Sheng WJ, Xue MT, Duan FX, Shen L, Ding SQ, Wang QY, Wang R, Lü HZ, Hu JG. Effect of morroniside on the transcriptome profiles of rat in injured spinal cords. Gene. 2022 May 20;823:146338.
10.Duan FX, Shi YJ, Chen J, Song X, Shen L, Qi Q, Ding SQ, Wang QY, Wang R, Lü HZ, Hu JG. The neuroprotective role of morroniside against spinal cord injury in
female rats. Neurochem Int. 2021 Sep;148:105105.
l 专利与奖励
（1）发明专利：一种能够靶向并阻断趋化因子受体的外泌体及其制备方法与应用, 2021年12月, 中国, ZL 2021 10 412359.X1（排名第一）
（2）获奖项目名称：损伤脊髓局部免疫微环境的探秘与干预研究、奖励类别（等级）：安徽省科学技术奖（二等奖）、授予单位：安徽省人民政府、获奖时间：2020、获奖者名单（排名第一）
二、研究方向
脊髓损伤与免疫等领域
三、指导学生情况：
已指导培养硕士研究生14名，其中多名学生获得奖学金等荣誉，所有学生均顺利毕业。
