姓 名：汪洪涛
性 别：男
出生年月：1974年7月
专业技术职称：教授
导师类别：硕导
电子邮箱：hongtaowang@bbmu.edu.cn
一、主要研究方向
1. 感染与免疫
2. 纳米颗粒疫苗设计与应用
二、个人简介
汪洪涛，医学博士，教授，硕士研究生导师。安徽省免疫学会理事，中国医学技术联盟第一届理事，安徽省预防医学会第六届卫生检验专业委员会常委，安徽省医学会检验医学分会第十一届委员会常委。长期致力于病原微生物生物学特性、感染与免疫及新型疫苗研发等。主持和参加多项国家、省部级科研项目，相关成果在《Cell Mol Biol Lett》《Virulence》《Int J Nanomedicine》等期刊发表，申请国家获批发明专利多项。
三、主持科研/教学项目
1. 蚌埠市科技项目，2023hm01，2024/01-2026/12，20万元，主持。
2. 呼吸系病临床基础安徽省重点实验室开放研究基金，HX2022Z02，2022/01-2024/12，15万元，主持。。
3. 安徽省自然科学基金项目，1908085MH252，2019/07-2022/06，10万元，主持。
四、代表性成果（论文/专利/专著等）
代表性论文：
1. Sihang Dong, Shuang Wu, Ke Liang, Hui Zhang, Fangzheng Guo, Yamin Song, Yanmei Hao, Zhongqing Qian, Xiaojing Wang, Tao Xu*, Hongtao Wang*. Immunogenicity Enhancement via Self-Assembled mi3 Nanoparticles Displaying ESAT-6 Antigen. International journal of nanomedicine (IF: 6.5), 2026, 21:558312.
2. Yamin Song, Fangzheng Guo, Huiting Dai, Xiaoyu Zhou, Sihang Dong, Hui Zhang, Zhongqing Qian, Baiqing Li, Xiaojing Wang, Tao Xu*, Hongtao Wang*. The mechanism regulating the cytotoxicity of γδ T cells activated by mycobacterium tuberculosis heat-resistant antigen based on RNA-seq analysis, Frontiers in immunology (IF: 5.9), 2026, 17:1707304.
3. Fangzheng Guo, Sihang Dong, Yamin Song, Yuanyuan Qian, Hairui Jiang, Wutong Zhang, Baiqing Li, Zhongqing Qian, Xiaojing Wang, Guangxian Xu*, Hongtao Wang*, Tao Xu*. Self-assembled ferritin tuberculosis nanovaccines targeting ESAT-6 and CFP-10 elicit potent immunogenicity in mice, international journal of biological macromolecules (IF: 8.5), 2025, 320(Pt 4):146101.
4. Fangzheng Guo, Sihang Dong, Yamin Song, Ge Xiesihan, Hairui Jiang, Zhongqing Qian, Xiaojing Wang, Hongtao Wang*, Tao Xu*. Self-assembled ferritin nanoparticles using SpyCatcher/SpyTag multimerization of Mycobacterium tuberculosis TB10.4 protein induce potent immunogenic, International immunopharmacology(IF: 4.7), 2025, 161:115019.
5. Fangzheng Guo, Yamin Song, Sihang Dong, Jing Wei, Baiqing Li, Tao Xu*, Hongtao Wang*. Characterization and anti-tuberculosis effects of γδ T cells expanded and activated by Mycobacterium tuberculosis heat-resistant antigen, Virulence (IF: 5.4), 2025, 16(1):2462092.
6. Jing Wei, Fangzheng Guo, Yamin Song, Tong Feng, Ying Wang, Kun Xu, Jianhan Song, Eldana Kaysar, Reyima Abdukayyum, Feiyang Lin, Kangsheng Li, Baiqing Li, Zhongqing Qian, Xiaojing Wang, Hongtao Wang*, Tao Xu*. Analysis of the components of Mycobacterium tuberculosis heat-resistant antigen (Mtb-HAg) and its regulation of γδ T-cell function. Cellular & molecular biology letters (IF: 10.2), 2024, 29(1):70.
7. Tao Xu, Chutong Wang, Minying Li, Jing Wei, Zixuan He, Zhongqing Qian, Xiaojing Wang, Hongtao Wang*. 2024, Mycobacterium tuberculosis PE_PGRS45 (Rv2615c) Promotes Recombinant Mycobacteria Intracellular Survival via Regulation of Innate Immunity, and Inhibition of Cell Apoptosis. Journal of microbiology (IF: 2.6). 62(1):49-62.
8. Fangzheng Guo, Jing Wei, Yamin Song, Baiqing Li, Zhongqing Qian, Xiaojing Wang, Hongtao Wang*, Tao Xu*. Immunological effects of the PE/PPE family proteins of Mycobacterium tuberculosis and related vaccines. Frontiers in Immunology (IF: 5.9), 2023, 14:1255920.
9. Jing Wei, Fangzheng Guo, Yamin Song, Kun Xu, Feiyang Lin, Kangsheng Li, Baiqing Li, Zhongqing Qian, Xiaojing Wang, Hongtao Wang*, Tao Xu*. Transcriptional analysis of human peripheral blood mononuclear cells stimulated by Mycobacterium tuberculosis antigen. Frontiers in Cellular and Infection Microbiology (IF:4.8), 2023, 13:1255905.
10. Tao Xu, Chutong Wang, Minying Li, Meili Yuan, Jing Wei, Baiqing Li, Zhongqing Qian, Ting Wang, Xiaojing Wang, Hongtao Wang*. Mycobacterium tuberculosis PE8 (Rv1040c) Promotes the Intracellular Survival of Recombinant Mycobacterium by Regulating Host Inflammatory Cytokines and Inhibiting Cell Late Apoptosis. 2023, DNA and Cell Biology (IF: 2.6), 42(5): 254-264.
专利：
1.汪洪涛，郭方正，许涛，魏婧，宋亚敏，董思航，钱中清，王效静，宋健涵，王颖，李康生。一种结核分枝杆菌耐热抗原的应用，2025年，中国，ZL 2024 1 0200775.7
2. 许涛，郭方正，汪洪涛，董思航，宋亚敏，吴双，梁珂，姜海瑞，钱中清，王效静。一种自组装铁蛋白纳米颗粒重组蛋白SFT及其制备方法和应用，2025年，中国，ZL202510275824.8
