姓名：胡建国
性别：男
职称：教授/研究员/主任技师
学历：博士研究生
学位：博士
最高学位的毕业院校：上海交通大学医学院
工作单位（到教研室或实验室层面）：蚌埠医科大学第一附属医院/炎症相关性疾病基础与转化研究安徽省重点实验室
学术领域：临床检验诊断学、神经生物学、免疫学
研究方向：（1）疾病的分子诊断与治疗靶点研发；（2）炎症性肠病的病理生理机制；（3）脊髓损伤病理机制及修复。
一、科研和教研成果：
· 科研项目：主持或参与的科研项目（国家级/省部级/厅局级），包括[项目名称]（项目编号、起止年限、资助经费）（近5年）。
1) 国家自然科学基金，面上项目，82471399，基于微血管内皮细胞线粒体自噬探讨SerpinE2调控血脊髓屏障对脊髓损伤的作用和机制，2025-01-01至2028-12-31，49万元，在研，主持
2) 安徽省卫生人才项目，人才项目，无，安徽省第一届卫生健康杰出人才培养对象，2022-12-31至2025-12-31，0万元，在研，主持
3) 安徽高校自然科学研究项目，创新团队项目，2023AH010067，炎症性肠病科研创新团队，2023-09-07至2025-09-06，0万元，在研，主持
4) 国家自然科学基金，面上项目，82071360，诱导型细胞因子白介素-11在脊髓损伤病理过程中的作用与机制，2021-01-01至2024-12-31，55万元，在研，主持
5) 安徽省卫生健康委科研项目，人才项目，无，安徽省创新创业领军人才特殊支持计划项目，2020-03-12至2023-03-11，30万元，结题，主持
6) 安徽高校自然科学研究项目，协同创新项目，GXXT-2020-020，Luminex 液相芯片高通量检测粪便人源性蛋白早期诊断结直肠肿瘤的技术研发，2020-12-01至2022-12-31，100万元，在研，主持
7) 国家自然科学基金，面上项目，81771343，莫诺苷对大鼠脊髓损伤的保护作用及其机制，2018-01-01至2021-12-31，60万元，结题，主持
· 论文发表：在[国内外知名期刊/会议]上发表学术论文（近5年）。（第一作者或通讯作者）
1) Song Xue*,Zhang Xiaofeng*,Zhang Min*,Liu Shengbao,Zhang Nuo,Liu Xinyue,Li Bohan,Li Jing,Geng Zhijun,Zuo Lugen,Wang Yueyue,Wang Lian,Hu Jianguo#. The JNK/P38 signaling pathway activated by Testin protects the intestinal epithelial barrier against Crohn's disease-like colitis. Chemico-Biological Interactions. 403 (2024) 111222. 中科院一区, IF=4.7.
2) Geng Zhijun*,Zuo Lugen*,Li Jing*,Yin Lixia,Yang Jingjing,Duan Ting,Wang Lian,Zhang Xiaofeng,Song Xue,Wang Yueyue,Hu Jianguo#. Ginkgetin improved experimental colitis by inhibiting intestinal epithelial cell apoptosis through EGFR/PI3K/AKT signaling. FASEB Journal. 2024;38(14):e23817. 中科院二区, IF=4.4.
3) Zhang Yuxin*,Hu Jianguo#,Chen Xiaojie,Li Jiaxin,Qi Qi#,Wang Xiaoxuan,Wang Ziyao,Wu Yimin,Xu Yibo,Zhang Su Hui. Hesperetin ameliorates spinal cord injury in rats through suppressing apoptosis, oxidative stress and inflammatory response. European Journal of Pharmacology. 2024.971:176541. 中科院二区, IF=5.0002.
4) Zhang Min*,Song Xue*,Liu Shengbao,Zhang Nuo,Yang Ming,Gao Pengcheng,Geng Zhijun,Zuo Lugen,Zhang Xiaofeng,Wang Lian,Wang Yueyue,Li Jing,Hu Jianguo#. Magnolin inhibits intestinal epithelial cell apoptosis alleviating Crohn’s disease-like colitis by suppressing the PI3K/AKT signalling pathway. International Immunopharmacology. 2024.134:112181. 中科院二区, IF=5.5999.
5) Wang Yueyue*,Song Xue*,Xia Yongsheng,Zhang Wenjing,Li Wenjie,Wang Yu,Li Jing,Geng Zhijun,Zhang Xiaofeng,Wang Lian,Zuo Lugen,Hu Jianguo#. Complanatuside A ameliorates 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice by regulating the Th17/Treg balance via the JAK2/STAT3 signaling pathway. FASEB Journal. 2024;38(10):e23667. 中科院二区, IF=4.8003.
6) Li Qingqing*,Li Jing*,Yin Lixia,Huang Ju,Liu Xinyue,Shi Jinran,Geng Zhijun,Song Xue,Wang Lian,Wang Yueyue,Zhang Xiaofeng,Zuo Lugen,Hu Jianguo#. Sophoricoside improved Crohn’s disease-like colitis by inhibiting intestinal epithelial cell apoptosis through PI3K/AKT signaling. International Immunopharmacology. 2024.131:111886. 中科院二区, IF=5.6000.
7) Fu Guiqiang*,Wang Yangyang*,Xu Yaomei,Bian Mingming,Zhang Lin,Yan Huazheng,Gao Jianxiong,Li Jinglu,Chen Yuqing,Zhang Nan,Ding Shuqin,Wang Rui,Li Jiangyan,Hu Jianguo#,Lü Hezuo#. Exosomes derived from vMIP-II-Lamp2b gene-modified M2 cells provide neuroprotection by targeting the injured spinal cord, inhibiting chemokine signals and modulating microglia/macrophage polarization in mice. Experimental Neurology. 2024.19:377:114784. 中科院二区, IF=5.2999.
8) Wang Lian*,Song Xue*,Zhou Yueqing*,Xia Yongsheng,Yang Zi,Chen Xiaohua,Shi Ruohan,Geng Zhijun,Zhang Xiaofeng,Wang Yueyue,Li Jing,Hu Jianguo#,Zuo Lugen#. Sclareol protected against intestinal barrier dysfunction ameliorating Crohn’s disease-like colitis via Nrf2/NF-B/MLCK signalling. International Immunopharmacology. 2024.133:112140. 中科院二区, IF=5.6000.
9) Geng Zhijun*,Li Jing*,Zuo Lugen*,Zhang Xiaofeng*,Wang Lian,Xia Yongsheng,Yang Jingjing,Yin Lixia,Song Xue,Wang Yueyue,Chai Damin,Deng Min,Ge Yuanyuan,Wu Rong,Hu Jianguo#. Intestinal adipocytes transdifferentiate into myofibroblast-like cells and contribute to fibrosis in Crohn's disease. Journal of Crohns & Colitis. 2024.. 中科院二区, IF=8.0000.
10) Xu Yibo*,Geng Zhijun*,Sun Yang,Zhu Guoqing,Xiao Linyu,Wang Zhiyuan,Li Bohan,Liu Xinyue,Shi Jinran,Song Xue#,Hu Jianguo#,Qi Qi#. Complanatuside A improves functional recovery after spinal cord injury through inhibiting JNK signaling-mediated microglial activation. European Journal of Pharmacology. 965:176287. 中科院二区, IF=5.
11) Zhang Zining*,Zuo Lugen*,Song Xue*,Wang Lian,Zhang Yan,Cheng Yang,Huang Ju,Zhao Tianhao,Yang Zi,Zhang Hao,Li Jing,Zhang Xiaofeng,Geng Zhijun,Wang Yueyue,Ge Sitang,Hu Jianguo#. Arjunolic acid protects the intestinal epithelial barrier, ameliorating Crohn’s disease-like colitis by restoring gut microbiota composition and inactivating TLR4 signalling. Phytomedicine. 2024.123:155223. 中科院一区, IF=7.9000.
12) Sun Yang*,Song Xue*,Geng Zhijun*,Xu Yibo,Xiao Linyu,Chen Yue,Li Bohan,Shi Jinran,Wang Lian,Wang Yueyue,Zhang Xiaofeng,Zuo Lugen,Li Jing,Lü Hezuo#,Hu Jianguo#. IL-11 ameliorates oxidative stress damage in neurons after spinal cord injury by activating the JAK/STAT signaling pathway. International Immunopharmacology. 2024.127:111367. 中科院二区, IF=5.6000.
13) Zhu Guoqing*,Song Xue*,Sun Yang,Xu Yibo,Xiao Linyu,Wang Zhiyuan,Sun Yijie,Zhang Liubaoju,Zhang Xiaofeng,Geng Zhijun,Qi Qi,Wang Yueyue,Wang Lian,Li Jing,Zuo Lugen,Hu Jianguo#. Esculentoside A ameliorates BSCB destruction in SCI rat by attenuating the TLR4 pathway in vascular endothelial cells. Experimental Neurology. 2023.369:114536. 中科院二区, IF=5.3000.
14) Zuo Lugen*,Geng Zhijun*,Song Xue*,Li Jing,Wang Yueyue,Zhang Xiaofeng,Ge Sitang,Wang Lian,Liu Guangyong,Zhang Lele,Xu Mengyu,Zhao Yajing,Shen Li,Ge Yuanyuan,Wu Rong,Hu Jianguo#. Browning of mesenteric white adipose tissue in Crohn's disease: a new pathological change and therapeutic target. Journal of Crohns & Colitis. 2023.17(8):1179-1192. 中科院二区, IF=8.0000.
15) Zhang Hao*,Zuo Lugen*,Li Jing*,Geng Zhijun,Ge Sitang,Song Xue,Wang Yueyue,Zhang Xiaofeng,Wang Lian,Zhao Tianhao,Deng Min,Chai Damin,Wang Qiusheng,Yang Zi,Liu Quanli,Qiu Quanwei,He Xuxu,Yang Yiqun,Ge Yuanyuan,Wu Rong,Zheng Lin,Li Jianjun,Chen Runkai,Sun Jialiang,Hu Jianguo#. Construction of a fecal immune-related protein-based biomarker panel for colorectal cancer diagnosis: a multicenter study. Frontiers in Immunology. 2023.14:1126217. 中科院二区, IF=8.786.
16) Li Jinglu*,Fu Guiqiang*,Wang Yangyang,Bian Mingming,Xu Yaomei,Zhang Lin,Chen Yuqing,Zhang Nan,Ding Shuqin,Wang Rui,,Tang Jie,Hu Jianguo#,Lü Hezuo#. The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis. PeerJ. 2023.11:e14929. 中科院三区, IF=2.7001.
17) Zuo Lugen*,Li Jing*,Zhang Xiaofeng*,Geng Zhijun,Song Xue,Wang Yueyue,Ge Sitang,Shi Ruohan,Zhou Yueqing,Ge Yuanyuan,Wu Rong,Hu Jianguo#. Aberrant mesenteric adipose extracellular matrix remodelling is involved in adipocyte dysfunction in Crohn’s Disease: the role of TLR-4-mediated macrophages. Journal of Crohns & Colitis. 2022.16(11):1762-1776. 中科院二区, IF=10.0200.
18) Zhang Xiaofeng*,Zuo Lugen*,Geng Zhijun,Song Xue,Li Jing,Ge Sitang,Jiang Yifan,Yang Zi,Liu Guangyong,Zhao Yajing,Zhao Hao,Yu Liang,Hu Jianguo#. Vindoline ameliorates intestinal barrier damage in Crohn's disease mice through MAPK signaling pathway. FASEB Journal. 2022.36(11):e22589. 中科院二区, IF=4.8003.
19) Li Jing*,Zuo Lugen*,Geng Zhijun,Li Qingqing,Cheng Yang,Yang Zi,Shi Ruohan,Zhou Yueqing,Nie Wenhu,Wang Yueyue,Zhang Xiaofeng,Ge Sitang,Song Xue,Hu Jianguo#. Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Crohn's disease -like colitis via the Axin2/GSK3β pathway. Cell Proliferation. 2022.55(10):e13292. 中科院一区, IF=8.7550.
20) Xue Mengtong*,Sheng Wenjie,Song Xue,Shi Yujiao,Geng Zhijun,Shen Lin,Wang Rui,Lü Hezuo#,Hu Jianguo#. Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization. CNS Neuroscience & Therapeutics. 2022.28(7):1059-1071. 中科院一区, IF=5.5002.
· 专利：
张文静;胡建国;张诺;夏勇生;杨子;张敏;肖林雨;一种可更换滤网的漏斗样过滤装置,2024-06-11,中国,CN 221107183 U
· 奖励：
1) 胡建国(2/5);基于脊髓损伤早期炎症的神经保护新策略,淮海科学技术奖委员会,科技创新奖,三等奖,2023(吕合作;胡建国;丁淑琴;陈雨晴;陈静)
2) 胡建国(2/5);损伤脊髓局部免疫微环境的探秘与干预研究,安徽省人民政府,科学技术奖（自然科学）,二等奖,2020(吕合作;胡建国;周建生;申林;王锐)
二、研究方向（需要有较具体的内容简介）与招生信息：（此段的介绍可有自己的特色）：
炎症性肠病、脊髓损伤修复等领域的研究工作。
三、指导学生情况：
已指导培养硕士研究生17名，其中多名学生获得国家奖学金、省级优秀毕业生及优秀论文奖等荣誉，并在学术界和工业界取得了优异成绩。
