姓名:汪洪涛,男,职称:教授,博士研究生,医学博士(东南大学)
学术领域:免疫学,研究方向:[感染与免疫,肿瘤免疫]
一、科研和教研成果:
· 科研项目:
(1) 呼吸系病临床基础安徽省重点实验室(科技厅重点实验室)开放研究基金(HX2022Z02),结核分枝杆菌耐热抗原MTB-HAg诱导的巨噬细胞极化分泌的外泌体对γδT细胞的调控作用机制研究,2022-01至2023-12,15万元,主持;
(2) 安徽省自然科学基金面上项目(1908085MH252),结核分枝杆菌PE_PGRS45蛋白调控宿主细胞免疫应答分子机制研究,2019-07至2022-06,10万元,主持;
(3) 市科技局重点项目,基于Ferritin纳米颗粒新型结核病疫苗的构建与免疫学评价,2023-01至2025-12,20万元,主持。
· 论文发表:
[1] Guo F, Wei J, Song Y, Li B, Qian Z, Wang X, Wang H*, Xu T*. Immunological effects of the PE/PPE family proteins of Mycobacterium tuberculosis and related vaccines. Front Immunol. 2023 Sep 27;14:1255920.
[2] Wei J, Guo F, Song Y, Xu K, Lin F, Li K, Li B, Qian Z, Wang X, Wang H*, Xu T*. Transcriptional analysis of human peripheral blood mononuclear cells stimulated by Mycobacterium tuberculosis antigen. Front Cell Infect Microbiol. 2023 Sep 25;13:1255905.
[3] Xu T, Wang C, Li M, Yuan M, Wei J, Li B, Qian Z, Wang T, Wang X, Wang H*. Mycobacterium tuberculosis PE8 (Rv1040c) Promotes the Intracellular Survival of Recombinant Mycobacterium by Regulating Host Inflammatory Cytokines and Inhibiting Cell Late Apoptosis. DNA Cell Biol. 2023 May;42(5):254-264.
[4] Xu T, Li M, Wang C, Yuan M, Chang X, Qian Z, Li B, Sun M, Wang H*. Codon Optimization, Soluble Expression and Purification of PE_PGRS45 Gene from Mycobacterium tuberculosis and Preparation of Its Polyclonal Antibody Protein. J Microbiol Biotechnol. 2021 Nov 28;31(11):1583-1590.
[5] Liu H, Li Y, Zhang J, Wu N, Liu F, Wang L, Zhang Y, Liu J, Zhang X, Guo S, Wang H*. Erb‑B2 Receptor Tyrosine Kinase 2 is negatively regulated by the p53‑responsive microRNA‑3184‑5p in cervical cancer cells. Oncol Rep. 2021 Jan;45(1):95-106.
[6] Wang H*, Kanmangne D, Li R, Qian Z, Xia X, Wang X, Wang T. miR‑30a‑3p suppresses the proliferation and migration of lung adenocarcinoma cells by downregulating CNPY2. Oncol Rep. 2020 Feb;43(2):646-654.
二、研究方向
感染与免疫和肿瘤免疫,特别聚焦于结核固有免疫的探究。
三、指导学生情况:
已指导培养硕士研究生10名,其中多名研究生获得国家奖学金,优秀三好学生等荣誉。